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Publications

Explore our latest scientific publications and research papers. 

Glioblastoma

We discovered that the tissue architecture in glioblastoma can be compositionally classified into three targetable and prognostically relevant tissue states. We targeted one of the pernicious tissue states in patient glioblastoma tissue and were able to abolish that signature with metabolic interventions. We are now testing several methods to target tissue states using our innovative slice culture model in collaboration with the Canoll-Bruce and Stockwell labs.  

Huntington's disease astrocyte dysfunction

We discovered neuroprotective and disease-associated astrocyte states from HD brain donors. This work has led us to identify several molecular targets we are pursuing in the lab as potential therapies to slow neurodegeneration.  Check out the transcriptomic and lipidomic datasets we generated.

Parkinson's disease

In our Nature Communications paper, we define the spatial landscape of glial pathology and T cell infiltration using TCRseq, snRNAseq, and spatial transcriptomics. We found that the niche of neurodegeneration harbors clonally expanded T cells, CD44+ astrocytes, and activated microglia. CD44 was involved in promoting neuroinflammatory signatures in CD44+ astrocytes, nominating it as a molecular target in PD pathogenesis.

Maturation defects in Huntington disease oligodendrocyte implicate metabolic pathways

This work, in collaboration with the Thompson lab at the University of California, Irvine (UCI), describes conserved maturation defects in oligodendrocyte lineage cells in HD brains and in mouse models. We discovered that metabolic pathways are at fault, and thiamine-biotin  supplementation reversed maturation defects in HD mouse models.

COVID-19

Our pioneering work described the neuropathology of COVID-19 and the phenotypes of astrocytes and microglia in the brain stem of COVID-19 victims. 

Astrocytes subtypes

Our latest paper in Cells describes the distribution of CD44+ astrocytes in human CNS, and the upregulation of CD44 in seizure and ischemia rodent models. 

Bibliography

  1.   Paryani, F., J.-S. Kwon, C. W. Ng, N. Madden, K. Ofori, A. Tang, H. Lu, J. Li, A. Mahajan, S. M. Davidson, A. Basile, C. McHugh, J. P. Vonsattel, R. A. Hickman, M. Zody, D. E. Houseman, J. E. Goldman, A. E. Yoo, V. Menon and O. Al-Dalahmah*. "Multi-omic analysis of Huntington disease reveals a compensatory astrocyte state." (2024). Nat Commun. Doi: 10.1038/s41467-024-50626-0, PMC11306246        
    * Corresponding author

  2.   Osama Al-Dalahmah*, Matti Lam*, Julie J. McInvale*, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A. Jakubiak, Rebekka Kuhn, Yoon A. Kim, Maria Caterina De Rosa, Claudia A. Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A. DeTure, Jean Paul Vonsattel, Zbigniew K. Wszolek, Dennis W. Dickson, Tanja Kuhlmann, Holm Zaehres, Hans R. Scholer, Andrew A. Sproul, Markus D. Siegelin, Philip L. De Jager, James E. Goldman, Vilas Menon, Peter Canoll, Gunnar Hargus (2024). Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons. Cell Stem Cell. 2024 https://doi.org/10.1016/j.stem.2024.03.013 PMID: 38626772
    * Co-First author 

  3.    Osama Al-Dalahmah, Alexander A Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E Sander Connolly, Carol M Troy, Guy M McKhann 2nd, James E Goldman. (2024). The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures. Cells. 10.3390/cells13020129.

  4.    Wenhui Qu, Matti Lam, Julie J. McInvale, Jason A. Mares, Sam Kwon, Nelson Humala, Aayushi Mahajan, Trang Nguyen, Kelly A. Jakubiak, Jeong-Yeon Mun, Thomas G. Tedesco, Osama Al-Dalahmah, Syed A. Hussaini, Andrew A. Sproul, Markus D. Siegelin, Philip L. De Jager, Peter Canoll, Vilas Menon & Gunnar Hargus. Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. Acta Neuropathologica. (2024). 10.1007/s00401-024-02755-5. PMID: 38918213

  5.    Wang H, Argenziano MG, Yoon H, Boyett D, Save A, Petridis P, Savage W, Jackson P, Hawkins-Daarud A, Tran N, Hu L, Al Dalahmah O, Bruce JN, Grinband J, Swanson KR, Canoll P, Li J. Biologically informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post treatment glioblastoma. npj Digit. Med. 7, 292 (2024). https://doi.org/10.1038/s41746-024-01277-4

  6.     Gopal Ramaswamy V, Ahirwar M, Ryan G, Dugger BN, Al Dalahmah O, Signaevsky M, Purohit DP, Haroutunian V, Finkbeiner S. Generalizable Prediction of Alzheimer Disease Pathologies with a Scalable Annotation Tool and an High-Accuracy Model. medRxiv [Preprint]. 2025 Feb 5:2025.02.03.25321603. doi: 10.1101/2025.02.03.25321603. PMID: 39974039; PMCID: PMC11838692.

  7.     Madden, N., Mei, Y. Z. J., Jakubiak, K., Li, J., Hargus, G., Goldman, J. E., & Al-Dalahmah, O*. (2023). The link between SARS-CoV-2 related microglial reactivity and astrocyte pathology in the inferior olivary nucleus. Front Neurosci, 17. https://doi.org/10.3389/fnins.2023.1198219 
    * Corresponding author

  8.    Pruvost, M., Patzig, J., Yattah, C., Selcen, I., Hernandez, M., Park, H. J., Moyon, S., Liu, S., Morioka, M. S., Shopland, L., Al-Dalahmah, O., Bendl, J., Fullard, J. F., Roussos, P., Goldman, J., He, Y., Dupree, J. L., & Casaccia, P. (2023). The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina. Cell Rep, 42(8), 112848. https://doi.org/10.1016/j.celrep.2023.112848 

  9.     Al-Dalahmah, O.*, Argenziano, M. G., Kannan, A., Mahajan, A., Furnari, J., Paryani, F., Boyett, D., Save, A., Humala, N., Khan, F., Li, J., Lu, H., Sun, Y., Tuddenham, J. F., Goldberg, A. R., Dovas, A., Banu, M. A., Sudhakar, T., Bush, E., Lassman, A. B., McKhann, G. M., Gill, B. J. A., Youngerman, B., Sisti, M. B., Bruce, J. N., Sims, P. A., Menon, V. * and Canoll, P*. (2023). Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states. Nat Commun, 14(1), 2586. https://doi.org/10.1038/s41467-023-38186-1 
    * Corresponding authors

  10.     Lim, R. G.#, Al-Dalahmah, O.#, Wu, J.#, Gold, M. P., et al. (2022). Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation. Nat Commun, 13(1), 7791. doi:10.1038/s41467-022-35388-x 
    # Co-First author

  11.  Wang L, Xing X, Zeng X, Jackson SR, TeSlaa T, Al-Dalahmah O, Samarah LZ, Goodwin K, Yang L, McReynolds MR, Li X, Wolff JJ, Rabinowitz JD, Davidson SM. Spatially resolved isotope tracing reveals tissue metabolic activity. Nat Methods. 2022 Feb;19(2):223-230. doi: 10.1038/s41592-021-01378-y. Epub 2022 Feb 7. PMID: 35132243.

  12.   Kiran T Thakur, Emily Happy Miller, Michael D Glendinning, Osama Al-Dalahmah, Matei A Banu, Amelia K Boehme, Alexandra L Boubour, Samuel S Bruce, Alexander M Chong, Jan Claassen, Phyllis L Faust, Gunnar Hargus, Richard A Hickman, Sachin Jambawalikar, Alexander G Khandji, Carla Y Kim, Robyn S Klein, Angela Lignelli-Dipple, Chun-Chieh Lin, Yang Liu, Michael L Miller, Gul Moonis, Anna S Nordvig, Jonathan B Overdevest, Morgan L Prust, Serge Przedborski, William H Roth, Allison Soung, Kurenai Tanji, Andrew F Teich, Dritan Agalliu, Anne-Catrin Uhlemann, James E Goldman, Peter Canoll, COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital, Brain, (2021). https://doi.org/10.1093/brain/awab148

  13.    Al‐Dalahmah, O, Nicholson, J, Draijer, S, Soares, L.C and Szele, F.G. (2020), Galectin‐3 diminishes Wnt signaling in the postnatal subventricular zone. Stem Cells. doi:10.1002/stem.3202

  14.     Al-Dalahmah, O, Sosunov, AA, Shaik, A, Ofori K, Liu Y, Vonsattel JP, Adorjan I, Menon V & Goldman JE. Single-nucleus RNA-seq identifies Huntington disease astrocyte states. acta neuropathol commun 8, 19 (2020). https://doi.org/10.1186/s40478-020-0880-6

  15.     Al-Dalahmah O*, Campos Soares L, Nicholson J, Draijer S, Mundim M, Lu VM, Sun B, Tyler T, Adorjan I, O'Neill E, Szele FG*. Galectin-3 increases postnatal subventricular zone astrocyte genesis via BMP signaling. Glia. (2019) doi: 10.1002/glia.23730
    * Corresponding authors

  16.     Bardella, C, Al-Dalahmah, O, Krell, D, Brazauskas, P, Tomkova, M, Al-Qahtani, K, Adam, J, Serres, S, Lockstone, H, and Freeman-Mills, L et al. Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis. Cancer Cell (2016).

  17.     Qaqish, B.M, Al-Dalahmah, O*, Al-Motassem, Y, Battah, A, and Ismail, S.S. Occupational Exposure to Pesticides And Occurrence Of The Chromosomal Translocation t(14;18) Among Farmers In Jordan. Toxicology Reports (2016).
    * Corresponding author.

  18.     Hillis, J.M, Davies, J, Mundim, M.V, Al-Dalahmah, O, and Szele, F.G. Cuprizone demyelination induces a unique inflammatory response in the subventricular zone. Journal of neuroinflammation (2016).

  19.    Young CC, Al-Dalahmah O, Lewis NJ, Brooks KJ, Jenkins MM, Poirier F, et al. Blocked angiogenesis in Galectin-3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke. Neurobiology of disease (2014).

  20.     Al-Khateeb E, Al-Zayadneh E, Al-Dalahmah O, Alawadi Z, Khatib F, Naffa R, et al. Relation between Copper, Lipid Profile, and Cognition in Elderly Jordanians. Journal of Alzheimer's disease (2014)

Reviews

21.    Soares, L. C., Al-Dalahmah, O., Hillis, J., Young, C. C., Asbed, I., Sakaguchi, M., O'Neill, E., & Szele, F. G. (2021). Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases. Cells, 10(11). https://doi.org/10.3390/cells10113047 

22.    David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, et al. COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside. npj Parkinsons Dis. 6, 18 (2020). https://doi.org/10.1038/s41531-020-00123-0

Case reports

23.    Al-Dalahmah, O. A., Wang, L., Hsiao, S. J., Lin, C. C., Mansukhani, M. M., Canoll, P., Bruce, J. N., & Zanazzi, G. (2022). Pineal region ganglioglioma: A neoplasm with a bimodal age distribution. Surg Neurol Int, 13, 245. https://doi.org/10.25259/SNI_443_2022 

24.    Osama Al-Dalahmah, Simona De Michele, David C Sperling, Kathleen M O'Toole, Alina Cornelia Iuga. Intrahepatic mass-forming extramedullary hematopoiesis in a patient with sickle cell disease: case report and literature review. AJSP: Reviews & Reports 25 (2020).

25.    Al-Dalahmah, O*, McEntire C, Niedt GW. Epithelial sheath neuroma: A case report and literature review. Clin Neuropathol. 2020; doi:10.5414/NP301251
* Corresponding author

26.    Al-Dalahmah, O*, Thakur, K.T, Nordvig, A.S et al. Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage. acta neuropathol commun 8, 147 (2020). https://doi.org/10.1186/s40478-020-01024-2.
* Corresponding author

27.    Miller, M. L., Griepp, D. W., Sun, Y., Tamir, S., Farber, R. S., Otten, M. L., & Al-Dalahmah, O*. (2022). A 53-year-old woman with a rapidly progressive, non-enhancing left frontotemporal lesion. Brain Pathol, e13125. doi:10.1111/bpa.13125
* Corresponding author
 

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